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When we treated mice exhibiting established EAE with 6-ECDCA, or the natural FXR ligand Chenodeoxycholic Acid (CDCA), clinical disease was ameliorated by (i) suppressing lymphocyte activation and proinflammatory cytokine production; (ii) reducing CD4+ T cells and CD19+ B cell populations and their expression of negative checkpoint regulators programmed cell death protein 1 (PD1), programmed death-ligand 1 (PD-L1), and B and T lymphocyte attenuator (BTLA); (iii) increasing CD8+ T cells and PD1, PDl-1, and BTLA expression; and (iv) reducing VLA-4 expression in both the T- and B-cell populations. Moreover, adoptive transfer of 6-ECDCA– or CDCA-treated donor cells failed to transfer disease in naive recipients. Thus, we show that FXR functions as a negative regulator in neuroinflammation and we highlight that FXR agonists represent a potential previously unidentified therapy for MS.
Objective: To study the chenodeoxycholic acid taurine (TCDCA) on immune function in mice. Methods: Flow cytometry was used double antibody labeling, hemolysin spectrophotometry, allergy method, carbon clearance method and turbidimetric assay were determined TCDCA of T cell subsets, serum antibody content, monocytes - macrophage phagocytic function and lysozyme content. Results: TCDCA significantly increased in mice peripheral blood CD4 ^ + and CD19 ^ + cell percentage and CD4 ^ + / CD8 ^ + ratio; high and low doses can improve TCDCA average serum hemolysin and lysozyme content, and may also enhance the monocyte - macrophage phagocytosis and inhibition of 
delayed type hypersensitivity in mice. Conclusion: TCDCA can significantly improve the body's immune mice.
The protoscolicidal effect of chenodeoxycholic acid (CDCA) was investigated. Freshly isolated protoscoleces were subjected to CDCA treatment (500, 1000, 2000, and 3000 μmol/L), and the effects on protoscoleces were investigated with the help of 0.1% eosin staining, electron microscopy, and colorimetric assay of caspase-3 like activity. Dose-dependent mortality of Echinococcus granulosus protoscoleces was observed within a few days of CDCA treatment. 

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