Yourlocation: Home > News > Use Chenodeoxycholic Acid to Dissolution of Cholesterol Gallstones
Seven women with gallstones were given 0.75 to 4.5 g per day of chenodeoxycholic acid, a primary bile acid, to promote micellar solubilization of cholesterol in bile. In Case 1 three stones that had remained unchanged in size during six years of observations disappeared after six months of treatment. A single stone in Case 2 and multiple calculi in Cases 3 and 4 progressively grew smaller during 14 to 22 months of chenodeoxycholic acid administration. Gallstone size did not change in the other three.

Chenodeoxycholic acid and total bile acid pool sizes (measured in two patients), which were reduced before therapy, were markedly expanded by chenodeoxycholic acid, and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients. Liver function and morphology remained normal; moderate dose-related diarrhea occurred. 

Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man. Also known as cholelithiasis gallstones, biliary system includes means gallbladder or bile duct stones occur in diseases, biliary tract infection belongs to common diseases. Press into diseased parts cholecystitis and cholangitis. After the formation of stones in the gallbladder, it can stimulate the gallbladder mucosa, not only can cause chronic inflammation of the gallbladder, and when impacted stones in the gallbladder neck or cystic duct, you can also cause secondary infections, leading to acute inflammation of the gallbladder. Since the stones of the gallbladder mucosa of chronic stimulation, it may also lead to gallbladder cancer occurs when there is such a report incidence of gallbladder cancer up to 1% to 2%.

Address:A3 Building, Dongli Aviation Business District,No.8,Pingying Road, Dongli District, Tianjin, P.R.China, 300300 Tel:+86-022-58602231 Fax:+86-022-58602232
Copyright © Tianjin NWS Biotechnology and Medicine Co. Ltd.