We observed a 67% reduction in PPARα mRNA levels when cells were treated with Chenodeoxycholic Acid as compared to cells treated with a vehicle control. The addition of ω3PUFA resulted in restoration to the level of control cells. We did not observe a significant difference in RXR mRNA levels, which was not unexpected, since abundance of RXR and its ligand, cis retinoic acid, typically precludes it from becoming rate-limiting in its role as a heterodimer partner with transcription factors. 
Treatment with Chenodeoxycholic Acid alone resulted in a 2-fold increase in LXRα mRNA levels that was attenuated by the addition of ω3PUFA. It is noteworthy that LXRα has been shown to have specific roles in regulating the innate immune response. Also, studies in LXRα null macrophages have shown LXRα has an important role in both innate and adaptive immunity, specifically in apoptosis. Cancer cells of diverse origin may be programmed to enter apoptosis by LXRα activation. Therefore, it is possible that LXRα may be an important mediator of CDCA-induced apoptosis, and its suppression by ω3PUFA may represent an additional pathway for the beneficial effect of ω3PUFA on apoptosis. Interestingly, FXR mRNA abundance was not affected by Chenodeoxycholic Acid or ω3PUFA treatment. 
If gallstones less than two centimeters in diameter, can not ,you can choose a conservative treatment without surgery. Chenodeoxycholic acid and ursodeoxycholic acid are primarily choosed. During treatment, pay attention to food hygiene, to avoid parasitic infections. Eat low-fat diet, eat more fresh vegetables, fruits, edible pork, chicken, duck, egg white. Eat fried foods, animal fats and offal , Shensi egg yolks, fish, crustaceans. avoid alcohol and spicy food. limiting fat, avoid stimulating gallbladder pain relief. dietary fat should be limited to about 20 grams before and after surgery, with the condition improved slightly increased to improve food color, flavor and stimulate the appetite. hanged greasy, fried, fried and fatty foods, such as pork, lamb, duck, foie gras, butter, pastries, cream cakes, etc. brewing beer wort contains calcium, oxalic acid, black nucleotides and purine nucleotide other acidic substances, they used each other, it can increase the body's uric acid, an important cause of kidney stones.