Piglet intestinal health and nutrition regulation, application of chenodeoxycholic acid (CDCA):
1. The intestine is the sensory organs of nutrients, in the intestine can feel the presence of nutrients, and some intestinal cells have memory, protein receptors can identify different nutrients, such as some can identify arg and so on.
2. Glp-2 (insulinotropic hormone) in the intestine can promote intestinal blood circulation and intestinal mucosal growth.
3. FGF19 (fibroblast growth factor) produced by the hormones in the intestine, can regulate the gastrointestinal, throughout the cycle, as the activation of the role of signal transmission, thereby promoting the rate of cholic acid. In pigs, TPN (pyridine triphosphate) acts on the liver, in which the secretion of cholic acid (CA) can be secreted.
4. Chenodeoxycholic acid(CDCA) under the application of FGF19 on the pig: the newborn pig for a period of 2 weeks test, fed FGF19 30mg /kg /d, the test results found that pig liver function was significant improved, including the flow of cholic acid, have also changed. Therefore, cyanodeoxycholic acid therapy can reduce the liver problem caused by TPN, the mechanism of activity may be through the CDCA treatment, the GLP-2 can be a good recovery.