(1) Preparation of ursodeoxycholic acid from cattle, sheep bile:
Bovine, Sheep Bile -- Water Decomposition -- Acid Precipitation -- Bile Acid -- Cholic Acid -- 3,7,24 - Trimethylate Cholic Acid -- 3,7,24 - Trimethyl -- 12 - Ketone Cholic acid -- 3,7,24-trimethyl ester--12-hydroxyamidobenzoic acid -- chenodeoxycholic acid -- oxidation -- ursodeoxycholic acid
(2) Preparation of ursodeoxycholic acid from chicken bile:
Chicken Bile -- Water Decomposition -- Acid Precipitation -- chenodeoxycholic acid -- oxidation -- Oxidic Acid
The above two routes, process comparison, cattle, sheep bile as raw materials prepare of ursodeoxycholic acid is more complex, and the yield of the products produced by the raw materials is also low, the content of impurities and the corresponding production cost is high.
So from the synthetic route, the process point of view, chicken bile as raw materials to prepare ursodeoxycholic acid is a better way.
The physical constants of ursodeoxycholic acid obtained from different raw materials are different in numerical value. This is mainly due to the different molecular structure of the main components of the raw materials used, and the difference between the processing method and the chemical reagents used, resulting in the inclusion of the final product contain different components of the by-product, so the physical constants are also different. Compared with chicken bile as raw material synthesis of ursodeoxycholic acid than cattle, sheep bile as raw material synthesis of ursodeoxycholic acid MP and specific rotation closer to the natural bear bile refined ursodeoxycholic acid.