Cerebrotendinous xanthomatosis (CTX) is known to be associated with osteoporosis and a higher incidence of bone fractures. However, the underlying pathogenesis is still unknown, and the effects of long-term replacement therapy with chenodeoxycholic acid (CDCA) on bone mineral density (BMD) have not been fully investigated. We studied 11 CTX patients aged 13–43 years. We performed dual-energy X-ray absorptiometry and assessed serum cholestanol and 25-hydroxyvitamin D (25-OHD) concentrations both at the time of diagnosis and after long-term treatment with CDCA. At baseline, we found low BMD in nine patients, cholestanol elevation in all subjects, and 25-OHD decrease  in nine. After a mean follow-up time of 30 months (range 24–36), no substantial clinical changes including bone fractures occurred; and we detected a significant increase of both planar and volumetric BMD as well as normalization of plasma cholestanol levels and increase of serum 25-OHD. 
Densitometric improvement following chenodeoxycholic Acid introduction was not correlated to changes of biochemical parameters. Our study confirms the presence of low bone mass in CTX and demonstrates that long-termchenodeoxycholic Acid treatment increases bone mineral content. In this respect, improvement of vitamin D intestinal absorption secondary to bile acid restoration could play an important role. Moreover, our data strongly suggest the utility of periodic bone density evaluation in CTX patients.
Using human implant for gallstone gallbladder method to observe the effect of biliary row of stone soup, made chenodeoxycholic Acid nine kinds of agents implanted gallstones. In weight before and after implantation of gallstones, bile appearance and presence of gallstones and other freshmen as an index, were analyzed and compared. The results showed that: Human Cholesterol stones after implantation rabbit gallbladder dissolved phenomenon, mixing pigment gallstones did not change significantly, and this role of bile RONGSHI voicing a significant relationship. Experimental certificate shows: Domestic CDCA promote implantation of cholesterol gallstones by dissolution of the biliary row of stone soup and walnut seems to reduce newborn gallstone effect. Furthermore, bile mucous substances have a certain significance in the occurrence and development of gallstones.