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A recent study showed that the farnesoid X receptor (FXR) -mediated transcriptional repressor, the V-Maf avian fibromyosarcoma gene homologue G (MAFG), directly inhibits bile acid synthesis-related genes, and regulation of bile acid composition, may have a significant impact on liver metabolism and disease. Bile acid is fat-soluble vitamins, fats, steroids in the intestinal tract absorption, and drug metabolism in the liver physiological regulator, but also activated FXR And membrane G protein-coupled receptor (TGR5) to regulate the metabolism of liver signaling molecules. FXR and TGR5 receptor agonists in the gastrointestinal system has anti-inflammatory effects, and the activation of bile acid receptors, which may prevent the occurrence of nonalcoholic fatty liver disease, diabetes and other diseases.The classic bile acid synthesis pathway in the human liver dominated by CYP 7A1 initiated synthesis of cholic acid (CA) and chenodeoxycholic acid (CDCA) as shown in Figure 1. CYP 8B1 is a synthetic enzyme for CA.CYP 27A1 catalyzes the formation of C24 bile acids in CYP27A1, which is initiated by CYP27A1, which is responsible for cholesterol oxidation and oxidative cholesterol in hepatocytes into bile acid in the mouse liver CDCA into α-mouse cholic acid (MCAs) and β-mouse cholic acid and the synthesis of bile acids are the same way the role of both bile acids in the intestine is reabsorption, intestinal flora will change some of the primary bile acid grade bile acids, which re-enter the liver through the enterohepatic circulation, inhibit CYP 7A1 and CYP 8B1 gene transcription and bile acid synthesis.

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