Here we study the combination of Chenodeoxycholic Acid and UDCA to treat disease. This method in optimizing dissolution therapy includes dual therapy with Chenodeoxycholic Acid and UDCA. A meta-analysis was performed that compared CDCA to UDCA to combination therapy with CDCA and UDCA. The meta- analysis only utilized randomized controlled trials and noted that UDCA was superior to CDCA therapy as monotherapies. In addition combination therapy with CDCA and UDCA was superior to UDCA or CDCA therapy alone; however, the effectiveness of combination therapy was based on only two randomized trials possibly skewing the true effectiveness of combination therapy.
The true effectiveness of UDCA over Chenodeoxycholic Acid is not clear,we do not understand the reason clearly, but tolerability remains the main advantage of UDCA. Compliance can be an issue with long term therapy with CDCA since significant side effects like diarrhea are more prevalent in patients who use Chenodeoxycholic Acid than those that are treated with UDCA. UDCA has shown some promise in gallstone dissolution, but keep in mind that several studies have demonstrated the recurrence rate to be as high as 61 % within 11 years. In addition, you should early detection and timely treatment about the diease.
UDCA is not definitive therapy but may be considered a tool to use in a select group of patients with cholesterol stones, where there risk of procedural intervention outweighs the potential benefit of more definitive therapy. Unfortunately there are no significant studies that help characterize in which populations dissolution therapy should be used. UDCA and Chenodeoxycholic Acid are not the only definitive therapies available for gallstone dissolution. Statins have become a popular and effective tool in the management of dyslipidemia. Statins work by inhibiting HMG-CoA reductase, the rate limiting enzyme in cholesterol synthesis. As a result, statins lead to a decrease in LDL, triglycerides, and VLDL within the body. Given the effect of statins on regulating cholesterol synthesis, it is natural to see how the application of these drugs affect biliary stones.