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Chenodeoxycholic acid(CDCA) was isolated from goose bile in 1924. In 1950, it has been chemically synthesized from cholic acid. In 1972 reported oral CDCA 0.75 ~ 4.0g / d cholesterol gallstone can be dissolved. Pharmacology: CDCA can inhibit liver microsomes of β-hydroxy-β-methyl glutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7α-hydroxylase, thereby reducing the synthesis of cholesterol and bile acids. After taking CDCA through the intestinal circulation, can be added to reduce the endogenous bile acid.
To study the relationship between abnormal bile acid metabolism and gallstone formation. Methods: The relationship between the mechanism of liver secretion and the changes of bile acid and the relationship between hydrophobic and hydrophobic balance were observed by RP-HPLC and in vitro culture of hepatocytes. Results: The ratio of GCDCA and GCA in gallstones was significantly lower than that in non-calculus group (P <0.05), while that of glycosyldeoxycholic acid (GDCA) The proportion increased significantly (P0.01). The bile acid HI values in the bile and hepatocyte culture supernatants of patients with gallstones were significantly higher than those in non - calculus patients. Conclusion: The bile acid secretion of hepatocytes in patients with gallstones is in pathological state, the ratio of binding to chenodeoxycholic acid and bound CA in bile is decreased, and the increase of binding rate of DCA is likely to be caused by impaired bile mechanism of liver.

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