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Results: In the 8-week reversion, the Chenodeoxycholic Acid intervention resulted in a dose-dependent reduction of obesity, dyslipidaemia and glucose intolerance, which could be largely explained by a transient decrease in food intake. The 3-week reversion revealed mild CDCA-dependent and food intake-independent induction of UCP1-mediated thermogenesis in interscapular BAT, negligible increase of UCP1 in subcutaneous WAT and a shift from carbohydrate to lipid oxidation.
Conclusions:  Chenodeoxycholic Acid could reverse obesity in cHF-fed mice, mainly in response to the reduction in food intake, an effect probably occuring but neglected in previous studies using cholic acid. Nevertheless, CDCA-dependent and food intake-independent induction of UCP1 in BAT (but not in WAT) could contribute to the reduction in adiposity and to the stabilization of the lean phenotype.
 Chenodeoxycholic Acid (CDCA) as template molecule, methacrylic acid as functional monomer, ethylene glycol dimethyl ester and trimethylolpropane trimethacrylate as the cross in chloroform by precipitation polymerization legal average particle size of 200 ~ 300nm molecularly imprinted polymer microspheres (MIPMS). use infrared spectroscopy to study the effect of the type of template molecule and functional monomer between TEM morphology of the polymer were characterized. the results indicated that the polymer microspheres formed during the synthesis of the two classes of binding sites of the molecular imprinted polymer specific adsorption CDCA has good performance, can be used for the separation of bile acids, purification, can affect the type of crosslinking agent molecules morphology and adsorption properties of imprinted polymer.

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