Bile acid is an important component of digestive juice and plays an important role in the process of fat metabolism. Primary bile acids are synthesized from hepatocytes, including cholic acid and chenodeoxycholic acid, both of which bind to glycine or taurine to form a combined primary bile acid, which removes glycine and taurine from the terminal ileum and colon part of the back into the blood, not absorbed part of the role of intestinal bacteria in the formation of secondary bile acids, including deoxycholic acid, lithocholic acid and trace ursodeoxycholic acid, part of the secondary bile acid can be through the intestinal cycle absorb. The process is involved in the digestion and uptake of a range of nutrients and affects the growth and reproduction of intestinal flora. Bile acid reflux into the upper gastrointestinal tract, metabolic disorders in the intestine, and deposition in the bile duct can participate in the occurrence and development of digestive tract tumors, must arouse great attention.
There is provided a composition and a method for treating a disease or disorder associated with a metabolic syndrome using a conjugate of a bile acid with a basic amino acid or a decarboxylated amino acid such as guanidinobutylamine. Also provided are bile acid-basic amino acid conjugates comprising chenodeoxycholic acid and an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as guanidinobutylamine.